Mental health challenges have become a severe burden to our society. In 2021, more than 150 million people lived with a mental disorder in the WHO European Region alone. Although the cause of the problem is complex and includes factors such as genetic predisposition, lifestyle, social factors, and traumatic experience, a common denominator is the manifestation of changes in neuronal signal transmission. Psychiatric medications that aim to adjust imbalance in synaptic signaling have only moderate-to-weak efficacy, high rates of side effects, and low remission rates, with 75% of patients relapsing within one year. Therefore, there is an urgent need to identify new therapeutic interventions that modulate neuronal signaling in an alternative way.