Hübschmann V, Korkut-Demirbaş M, Siegert S, „Assessing in vitro microglia identity and function by immunostaining, phagocytosis, calcium activity, and inflammation assay”, STAR Protocols, 2022 accepted. https://doi.org/10.1016/j.xpro.2022.101866
Colombo G, Cubero RJA, Kanari L, Venturino A, Schulz R, Scolamiero M, Agerberg J, Mathys H, Tsai L-H, Chachólsk W, Hess K, Siegert S, “A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes”, Nature neuroscience, 2022 Sep 30. https://doi.org/10.1038/s41593-022-011676.
*Commentary: Ascoli GA, JCN 2022, https://doi.org/10.1002/cne.25429
Schulz R, Korkut-Demirbaş M, Venturino A, Colombo G, Siegert S, “Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses”, Nature Communications, 2022, 13(1):4728, https://doi.org/10.1038/s41467-022-32390-1
Bartalska K, Hübschmann V, Korkut-Demirbaş M, Cubero RJA, Venturino A, Rössler K, Czech T, Siegert S, “A systematic characterization of microglia-like cell occurrence during retinal organoid differentiation”, iScience, 2022, 25(7):104580, https://doi.org/10.1016/j.isci.2022.104580
2021
Venturino A, Schulz R, de Jesus-Cortex H, Reilly-Andujar F, Maes ME, Nagy B, Cubero RJA, Colombo G, Schoot Uiterkamp FE, Bear M, Siegert S, “Microglia dismantle mature perineuronal nets upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain”, Cell Reports, 2021, 36(1):109313, https://doi.org/10.1016/j.celrep.2021.109313
Evaluated by F1000 by Wu L and Bosco D. https://facultyopinions.com/prime/740425005
Venturino A, Siegert S, “Minimally-invasive methods and quantification for microglia-mediated perineuronal net disassembly”, STAR Protocols, 2021; 2(4); 101012, https://doi.org/10.1016/j.xpro.2021.101012
Maes ME, Wögenstein GM, Colombo G, Casado-Polanco R, Siegert S, “Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment”, Mol Ther Methods Clin Dev, 2021; 23:210-224, https://doi.org/10.1016/j.omtm.2021.09.006
2019
Maes ME, Wögenstein GM, Colombo G, Casado-Polanco R, Siegert S, “Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment”, Mol Ther Methods Clin Dev, 2021; 23:210-224, https://doi.org/10.1016/j.omtm.2021.09.006
2016
Tsai L-H, Siegert S, “How microRNAs are involved in “splitting the mind”, JAMA Psychiatry, 2016; 73(4): 409-10, https://doi.org/10.1001/jamapsychiatry.2015.3144
2015
Mungenast AE*, Siegert S*$, Tsai L-H, “Modeling Alzheimer’s disease with human induced pluripotent stem (iPS) cells”, Molecular and cellular neuroscience 2015; 73:13-31, https://doi.org/10.1016/j.mcn.2015.11.010 *contributed equally, $corresponding author
Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai L-H, “The schizophrenia risk gene miR-137 alters presynaptic plasticity”, Nature Neuroscience 2015; 18(7): 1008-16, https://doi.org/10.1038/nn.4023
Highlighted in two preview articles:
Yates D. Nat Rev Neurosci. 2015, https://doi.org/10.1038/nrn3989
Han et al. Nat. Neurosci. 2015, https://doi.org/10.1038/nn.4045
Rei D, Mason X, Gräff J, Seo J, Rudenko A, Wang J, Rueda R, Siegert S, Cho S, Canter RG, Mungenast A, Deisseroth K, Tsai L-H, “The BLA bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway”, Proc Natl Acad Sci USA 2015; 112(23): 7291-6, https://doi.org/10.1073/pnas.1415845112
2012
Siegert S, Cabuy E, Gross Scherf B, Kohler H, Panda S, Le, Y-Z, Fehling HJ, Gaidatzis D, Stadler M, Roska B, “Transcription factor code and disease map for retinal cell types”, Nature Neuroscience 2012; 15(3): 487-95, https://doi.org/10.1038/nn.3032
Awarded the SWISS OphthAWARD in the category “Best experimental work”
2010
Busskamp V, Duebel J, Balya D, Fradot M, Viney TJ, Siegert S, Groner AC, Cabuy E, Forster V, Seeliger M, Biel M, Humphries P, Paques M, Mohand-Said S, Trono D, Deisseroth K, Sahel JA, Picaud S, Roska B, “Genetic reactivation of cone photoreceptors restores complex visual responses in Retinitis pigmentosa”, Science 2010; 329(5990): 413-7, https://doi.org/10.1126/science.1190897
Highlighted in two preview articles:
Bodo C. Nat Rev Neurosci. 2010, https://doi.org/10.1038/nrn2893
Cepko C. Science. 2010, https://doi.org/10.1126/science.1194086
2009
Siegert S, Gross Scherf B, Del Punta K, Didkovsky N, Heintz N, Roska B, “Genetic address book for retinal cell types”, Nature Neuroscience 2009; 12(9): 1197-204, https://doi.org/10.1038/nn.2370
Münch TA, da Silveira RA, Siegert S, Viney TJ, Awatramani GB, Roska B, “Approach sensitivity in the retina processed by a multifunctional neuronal circuit”, Nature Neuroscience 2009 Oct;12(10):1308-16. https://doi.org/10.1038/nn.2389
Highlighted in a news and views article: Oesch N. et al. Nat Neurosci. 2009, https://doi.org/10.1038/nn1009-1209
2007
Viney TJ, Balint K, Hillier D, Siegert S, Boldogkoi Z, Enquist LW, Meister M, Cepko CL Roska B, “Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing”, Current Biology 2007 Jun 5; 17(11): 981-8 https://doi.org/10.1016/j.cub.2007.04.058
2006
Siegert S, Schnierle P, Schnierle BS, “Novel anti-viral therapy: Drugs that blocks HIV entry at different target sites”, Mini Reviews in Medicinal Chemistry 2006 May; 6(5): 557-62. Review, https://doi.org/10.2174/138955706776876267
2005
Siegert S, Thaler S, Wagner R, Schnierle BS, “Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors“, AIDS Research and Therapy 2005 Sep 12, 2:7 https://doi.org/10.1186/1742-6405-2-7